External Analgesic/Skin Protectant. For relief from pain and itching due to poison ivy, poison sumac, insect bites, poison oak, and minor skin irritation. Compare to the active ingredients of Caladryl Clear. Pramoxine topical (for the skin) is used to treat pain or itching caused by insect bites, minor burns or scrapes, hemorrhoids, and minor skin rash, dryness, or itching. Pramoxine topical is also used to treat chapped lips, and pain or skin irritation caused by coming into contact with poison ivy, poison oak, or poison sumac.